讲座题目:Robust joint models for complex longitudinal and survival data
主 讲 人:吴浪
讲座时间:2024年6月6日(周四)14:00-15:30
讲座地点:6号学院楼500会议室
主办单位:77779193永利官网、浙江省2011协同创新中心(数据科学与大数据分析协同创新中心)
摘 要:
In a survival model with a time-dependent covariate, the covariate may be left censored due to a lower detection limit and its observed values may contain outliers. Motivated from an HIV vaccine study, we propose a robust method for joint models of longitudinal and survival data, where the outliers in longitudinal data are addressed using a multivariate t-distribution for b-outliers and using an M-estimator for e-outliers. We also propose a computationally efficient method for approximate likelihood inference. The proposed method is evaluated by simulation studies. Based on the proposed models and method,we analyze the HIV vaccine data and find a strong association between longitudinal biomarkers and the risk of HIV infection.
主讲人简介:
吴浪,华盛顿大学统计学博士,哈佛大学生物统计学博士后,加拿大不列颠哥仑比亚大学(UBC)统计系终身教授。吴浪教授的研究主要来自对健康科学数据集的分析,例如艾滋病/艾滋病病毒研究、癌症研究或疫苗研究。主要关注点是当存在缺失值、删失值、测量误差和异常值的情况下对纵向数据进行分析。吴浪教授研究成果丰硕,共出版专著2部,发表60余篇学术论文,主持加拿大国家自然科学基金项目多项。
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